Susceptibility of New Entrant University Students in Sri Lanka to Varicella Zoster Infection

Abstract

To investigate the susceptibility of Sri Lankan new entry university students to varicella zoster virus (VZV) infection, a cross-sectional descriptive study was carried out among new entrant medical and engineering students of the University of Peradeniya, Sri Lanka. Self-reported history of chicken pox was studied first, followed by serological evaluation for VZV IgG antibodies. A total of 451 students participated in the study out of which 189 (41.9%) reported a history of chicken pox. Median age of reported age of acquiring the disease was 14 years with an interquartile range of 10 to 17 years. Only 25% of the population reported history of infection prior to age of 10 years. The seropositive rate of VZV IgG antibodies among undergraduates with a negative history of chicken pox was 10.1% ( 25/247). The present study indicates that nearly half (222/436) of the study population (50.9%, 95% CI 46.2-55.6) was susceptible to VZV infection