Qualitative and quantitative dermatoglyphics of chronic kidney disease of unknown origin (CKDu) in Sri Lanka

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dc.contributor.author Wijerathne, Buddhika.Thilanga.Bandara
dc.contributor.author Meier, Robert.John
dc.contributor.author Salgado, Sujatha.Senadeera
dc.contributor.author Agampodi, Suneth.Buddhika
dc.date.accessioned 2022-12-21T10:03:38Z
dc.date.available 2022-12-21T10:03:38Z
dc.date.issued 2019-06-06
dc.identifier.citation Journal of Physiological Anthropology (2020) en_US
dc.identifier.uri http://repository.rjt.ac.lk/handle/123456789/5424
dc.description.abstract Background: Dermatoglyphics has been used widely in fields of medicine as a non-invasive diagnostic tool and an early assessment of risk for certain medical conditions. It reflects disturbances in fetal development during early prenatal weeks 14–22 when fingerprints develop. Dermatoglyphic asymmetry has been used to measure developmental instability during a specific period of human fetal development. Thus, the present study was planned to investigate whether digital and palmar dermatoglyphics of chronic kidney disease of unknown origin (CKDu) patients in Sri Lanka are different from healthy people. Methods: A case control study was carried out among CKDu patients (90 males, 90 females) from a CKDu endemic area and gender-matched two control groups; one group from a CKDu endemic region (90 males, 90 females) and another group from a CKDu non-endemic region (90 males, 90 females). Dermatoglyphics were obtained using photographic methods. Both qualitative and quantitative dermatoglyphic variables were defined and analyzed according to standard criteria. Both directional (DA) and fluctuating asymmetry (FA) were assessed. Results: Several qualitative dermatoglyphic variables had significant association with CKDu. The triradii a1 variable was less evident in palms of CKDu cases in both genders when compared to both control groups. The FA of pattern discordance (right vs left hands) between CKDu cases and control group were significant in several digits. The FA of the ridge count was found significant in several digits, and also significant for A-B ridge count and total ridge count. Conclusion: Based on these results, it is proposed that the mechanisms responsible for the development of CKDu might be associated with those responsible for FA observed in CKDu patients. Accordingly, a diagnostic tool based on FA could be developed for predicting risk prior to the development of CKDu en_US
dc.language.iso en en_US
dc.publisher Springer Nature en_US
dc.subject Chronic kidney disease, Dermatoglyphics, Fluctuating asymmetry, Prenatal stress, Sri Lanka en_US
dc.title Qualitative and quantitative dermatoglyphics of chronic kidney disease of unknown origin (CKDu) in Sri Lanka en_US
dc.type Article en_US


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