Abstract:
Sri Lanka boasts an exceptional biodiversity that fosters a wealth of flora
with therapeutic properties. However, traditional medical practices and herbal prod-
uct formulations often restrict their use to a limited number of species, and vast res-
ervoirs of valuable medicinal plants have still been underutilized. The present review
focused on evaluating five selected underutilized medicinal plants in Sri Lanka: Ag-
eratum conyzoides (Hulanthala), Artocarpus gomezianus (Kosgonna), Euphorbia
hirta (Kapumkeeriya), Plectranthus zeylanicus (Iriweriya), and Piper sarmentosum
(Gas Thippili). Plant species were selected based on the details of pharmacopoeias
and ethnobotanical surveys. Scientific data published on ethnomedicinal uses, phyto-
chemistry, and pharmacological properties of selected plants during the past 20 years
were collected from PubMed, ScienceDirect, and Google Scholar. Then, the collected
data were reviewed to determine how they could be utilized in the herbal products of
Sri Lanka. It was found that these plants contain many valuable phytochemicals, in-
cluding alkaloids, flavonoids, phenolic compounds, and terpenoids, that are predom-
inantly responsible for their medicinal properties. These phytochemicals have been
investigated in vitro and in vivo for various bioactivities, especially anti-microbial,
antioxidant, and anti-inflammatory properties. Most of these bioactivities are in ac-
cordance with the ethnobotanical uses of these plants. It was confirmed that these
plants had not been utilized mainly due to the lack of ethnobotanical knowledge and
have not often been included in the pharmacopoeias. It is also shown that these plants
can be utilized in a diverse array of herbal products, including novel cosmeceuticals
and pharmaceuticals. Further research is needed to evaluate the clinical efficacy of
these plants. In conclusion, the data analyzed in this review will aid researchers in
executing more studies on the above-mentioned medicinal plants and improve their
utilization. This, in turn, prevents the overexploitation of frequently used medicinal
plants and thus improves the sustainable utilization of biodiversity.
