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Faculty of Medicine and Allied Sciences: Recent submissions

  • Genetic Overlap Between Type 2 Diabetes and Depression in a Sri Lankan Population Twin Sample 
    Kan, Carol.M.R.C; Jayaweera, Kaushalya; Adikari, Anushka; Siribaddana, Sisira; Helena, F.R.C.P; Zavos, M.S (2020-02)
    Objective: Results from twin studies examining the genetic overlap between type 2 diabetes and depression are currently inconclusive. This question has not been addressed in non-Western populations. We aimed to examine ...
  • The relationship between independent and dependent life events and depression symptoms in Sri Lanka: a twin and singleton study 
    Zavos, Helena.M.S; Dalton, Bethan; Jayaweera, Kaushalya; Harber‑Aschan, Lisa; Pannala, Gayani; Adikari, Anushka; Hatch, Stephani.L; Siribaddana, Sisira; Sumathipala, Athula; Hotopf, Matthew; Rijsdijk, Frühling.V (2018-10-30)
    Purpose Life events have been associated with a variety of mental health conditions including depression. There is a scarcity of research in South Asia exploring the aetiology of independent and dependent life events and ...
  • Genetic and environmental variation in educational attainment: an individual‑based analysis of 28 twin cohorts 
    Silventoinen, Karri; Jelenkovic, Aline; Sund, Reijo; Latvala, Antti; Honda, Chika; Inui, Fujio; Tomizawa, Rie; Watanabe, Mikio; Sakai, Norio; Rebato, Esther; Busjahn, Andreas; Tyler, Jessica; Hopper, John.L; Ordoñana, Juan.R.; Sánchez‑Romera, Juan.F; Colodro‑Conde, Lucia; Calais‑Ferreira, Lucas; Oliveira, Vinicius.C; Ferreira, Paulo.H; Medda, Emanuela; Nisticò, Lorenza; Toccaceli, Virgilia; Derom, Catherine.A.; Vlietinck, Robert.F; Loos, Ruth.J.F; Siribaddana, Sisira.H; Hotopf, Matthew; Sumathipala, Athula; Rijsdijk, Fruhling; Duncan, Glen.E; Buchwald, Dedra; Tynelius, Per; Rasmussen, Finn; Tan, Qihua; Zhang, Dongfeng; Pang, Zengchang; Magnusson, Patrik.K.E; Pedersen, Nancy.L; Aslan, Anna.K.Dahl; Hwang, Amie.E; Mack, Thomas.M; Krueger, Robert.F; McGue, Matt; Pahlen, Shandell; Brandt, Ingunn; Nilsen, Thomas.S.; Harris, Jennifer.R; Martin, Nicholas.G; Medland, Sarah.E; Montgomery, Grant.W; Willemsen, Gonneke; Bartels, Meike; Beijsterveldt, Catharina.E.M.van; Franz, Carol.E; Kremen, William.S; Lyons, Michael.J.; Silberg, Judy.L; Maes, Hermine.H; Christian, Kandler; Nelson, Tracy.L; Whitfeld, Keith.E; Corley, Robin.P; Huibregtse, Brooke M.; Gatz, Margaret; Butler, David.A; Tarnoki, Adam.D; Tarnoki, David.L; Park, Hang.A; Lee, Jooyeon; Lee, Soo.Ji; Sung, Joohon; Yokoyama, Yoshie; Sørensen, Thorkild.I.A; Boomsma, Dorret.I; Kaprio, Jaakko (Department of Social Research, Faculty of Social Sciences, University of Helsinki, 2020-05-13)
  • A case series of distal renal tubular acidosis, Southeast Asian ovalocytosis and metabolic bone disease 
    Gunaratne, W.M.S.N; Dissanayake, D.M.D.I.B; Jayaratne, K.A.D.S; Premawardhana, N.P; Siribaddana, Sisira (Springer Nature, 2020-02-17)
    Background: Familial distal renal tubular acidosis (dRTA) associated with mutations of solute carrier family 4 membrane − 1 (SLC4A1) gene could co-exist with red cell membrane abnormality, Southeast Asian ovalocytosis ...
  • The Sri Lankan twin registry biobank: South Asia’s first twin biobank 
    Jayaweera, Kaushalya; Warnakula, Lakshan; Dissanayake, Lasith; Adikari, Anushka; Siribaddana, Sisira; Zavos, Helena.M.S; Rijsdijk, Fruhling; Zunszain, Patricia.A; Pariante, Carmine.M; Glozier, Nick; Hotopf, Matthew; Sumathipala, Athula (Cambridge University Press, 2020-01-07)
    Introduction. Biobanks are a valuable resource for creating advancements in science through cutting-edge omics research. Twin research methods allow us to understand the degree to which genetics and environmental factors ...
  • Hydroxychloroquine for post-exposure prophylaxis of COVID-19 among naval personnel in Sri Lanka: study protocol for a randomized, controlled trial 
    Niriella, Madunil.A; Ediriweera, Dileepa.S; De Silva, Arjuna.P; Premarathne, Ranjan; Balasooriya, Priyantha; Kaluthanthri, D.Duminda; Malavige, Neelika.G.; Wanigasuriya, Kamani; Lekamwasam, Sarath; Kularathne, Senanayake.A; Siribaddana, Sisira; de Silva, Hithanadura.J; Jayasinghe, Saroj (Springer Nature, 2020-05-18)
    Background: The first case of a coronavirus 2019 (COVID-19) infection in a Sri Lankan was reported on March 11, 2020. The situation in Sri Lanka changed with the rapid increase of personnel contracting COVID-19 in a naval ...
  • Melioidosis after a long silence in Sri Lanka: an environmental hazard and dilemma in diagnosis, with recovery and longitudinal follow-up for 13 years: a case report 
    Pathirage, Manoji.M.K; Kularatne, Senanayake.A.M; Weerakoon, Kosala.G (Springer Nature, 2019-04-30)
    Background: Melioidosis is a potentially fatal bacterial infection caused by Burkholderia pseudomallei. The existence of melioidosis in Sri Lanka was once unheard of, and entertaining it as a diagnosis in clinical practice ...
  • Features of COVID-19 patients detected during community screening: A study from a rural hospital in Sri Lanka 
    Senanayake, Anuranga.Prabuddhi; Indrakantha, Duminda; Sumathipala, Saranga; Wanigasuriya, Kamani; Kularathne, Senanayake; Lekamwasam, Sarath; Jayasinghe, Saroj; De Silva, Hithanadura.Janaka; Siribaddana, Sisira (2020-06-10)
    We studied the clinical course and virus shedding of all patients referred to Welikanda Hospital, in one month. There were 53 positives for COVID-19 by PCR. 24 (45%) were male, with an age range of 11-94 years. Of ...
  • Time delays in treatment of snakebite patients in rural Sri Lanka and the need for rapid diagnostic tests 
    Silva, Anjana; Hlusicka, Jiri; Siribaddana, Nipuna; Waiddyanatha, Subodha; Pilapitiya, Senaka; Weerawansa, Prasanna; Lokunarangoda, Niroshan; Thalgaspitiya, Sujeewa; Siribaddana, Sisira; IsbisterI, Geoffrey.K (2020-11-30)
    Delays in treatment seeking and antivenom administration remain problematic for snake envenoming. We aimed to describe the treatment seeking pattern and delays in admission to hospital and administration of antivenom in ...
  • The Utility of Novel Renal Biomarkers in Assessment of Chronic Kidney Disease of Unknown Etiology (CKDu): A Review 
    Gunasekara, T.D.K.S.C; De Silva, P.Mangala.C.S; Herath, Chula; Siribaddana, Sisira; Siribaddana, Nipuna; Jayasumana, Channa; Jayasinghe, Sudheera; Cardenas-Gonzalez, Maria; Jayasundara, Nishad (2020-11-17)
    Chronic Kidney Disease (CKD) is a globally prevalent non-communicable disease with significant mortality and morbidity. It is typically associated with diabetes and hypertension; however, over the last two decades, an ...
  • A primary human T-cell spectral library to facilitate large scale quantitative T-cell proteomics 
    Weerakoon, Harshi.; Potriquet, Jeremy.; Shah, Alok K.; Reed, Sarah.; Jayakody, Buddhika.; Kapil, Charu.; Midha, Mukul.K.; Moritz, Robert L.; Lepletier, Ailin.; Mulvenna, Jason.; Miles, John J.; Hill, Michelle.M. (Springer Nature, 2020-07-11)
    Background & Summary T-cells are the central regulators of adaptive immunity and among the most diverse cellular compartment in human physiology1 . While advanced transcriptomics, including single cell transcriptomics, ...
  • In-Vitro Neutralization of the Neurotoxicity of Coastal Taipan Venom by Australian Polyvalent Antivenom: The Window of Opportunity 
    Madhushani, Umesha; Isbister, Geoffrey.K; Tasoulis, Theo; Hodgson, Wayne.C; Silva, Anjana (Creative Commons Attribution, 2020-10-15)
    Coastal taipan (Oxyuranus scutellatus) envenoming causes life-threatening neuromuscular paralysis in humans. We studied the time period during which antivenom remains effective in preventing and arresting in vitro ...
  • First Authenticated Case of a Bite by Rare and Elusive Blood-Bellied Coral Snake (Calliophis haematoetron) 
    Silva, Anjana; Jayakody, Shyamalee; Ranasinghe, Nishadi; Manawaduge, Asanka; Perera, Kavinda (Blood-Bellied Coral Snakebite, 2020-05)
    Blood-bellied coral snake (Calliophis haematoetron) is a recently discovered forest-dwelling species of ela pid hitherto known from 3 specimens found from central Sri Lanka. Herein we describe the first authenti cated case ...
  • Bedside Coagulation Tests in Diagnosing Venom-Induced Consumption Coagulopathy in Snakebite 
    Wedasingha, Supun; Isbister, Geoffrey; Silva, Anjana (Creative Commons Attribution, 2020-08-14)
    Venom-induced consumption coagulopathy is the most important systemic effect of snake envenoming. Coagulation tests are helpful to accurately and promptly diagnose venom-induced consumption coagulopathy and administer ...
  • Intra-Specific Venom Variation in the Australian Coastal Taipan Oxyuranus scutellatus 
    Tasoulis, Theo; Silva, Anjana; Veerati, Chander.Punnam; Baker, Mark; Hodgson, Wayne.C; Dunstan, Nathan; Isbister, Geoffrey.K (2000-06-25)
    Intra-specific venom variation has the potential to provide important insights into the evolution of snake venom, but remains a relatively neglected aspect of snake venom studies. We investigated the venom from 13 ...
  • Sex-, age- and education-adjusted norms for the WHO/ UCLA version of the Rey Auditory Verbal Learning Test for Sinhala-speaking Sri Lankan adults 
    Dassanayakea, Tharaka.Lagath.; Hewawasamb, Chandana.; Baminiwatta, Anuradha.; Samarasekara, Narendra.; Ariyasinghe, Dewasmika.Indrapali. (2020-05-21)
    Objective: The aim of this study was to create sex-, age- and education-adjusted norms for the WHO/UCLA version of the Rey Auditory Verbal Learning Test (RAVLT) for Sinhala-speaking Sri Lankan adults. Methods: Five-hundred ...
  • Public health programmes to promote mental health in young people: a systematic integrative review protocol 
    Wickramasinghe, Nuwan.Darshana.; Samarutilake, Nelum; Wettasinghe, Mihiri.Chami.; Feiler, Julie.; Morgan, Antony.; Kousoulis, Antonis.A.; Bortel, Tine.Van. (2020-01-24)
    Introduction In light of the ever-growing mental health disease burden among young people worldwide, we aim to systematically review the global literature to identify the public health programmes targeted at promoting ...
  • A new ischemic grading system to aid combat extremity vascular injury decision making 
    Ratnayake, Amila; Reva, Viktor.A.; Bala, Miklosh.; Jayatilleke, Achala.U.; Thalgaspitiya, Sujeewa.P.B.; Kauvar, David.S.; Worlton, Tamara.J. (2020-08-07)
    Abstract Introduction In resource limited combat settings with frequent encounters of mass casualty incidents, the decision to attempt limb salvage versus primary amputation is refined over time based on experience. ...
  • A critical appraisal of impact of compounding factors in limb salvage decision making in combat extremity vascular trauma 
    Ratnayake, Amila.S,; Bala, M.; Fox, C.J.; Jayatilleke, A.U.; Thalgaspitiya, S.P.B.; Worlton, T.J. (2020-04-28)
    ABSTRACT Objective For more than half a century, surgeons who managed vascular injuries were guided by a 6-hour maximum ischaemic time dogma in their decision to proceed with vascular reconstruction or not. Contemporary large ...
  • Penetrating Injuries Following Spotted Deer Axis axis ceylonensis Attack 
    Thalgaspitiya, Sujeewa.P.B.; Wijekoon, Heshan.S.; Wijerathne, Buddhika.T.B. (2019-11)

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